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“Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and diabetic peripheral neuropathy” – Nature article: Shows prolonged metformin use correlates with lower B12 and more severe diabetic neuropathy
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Strength:70mg
An increase in PGD2 levels can create a vicious cycle – triggering mast cell hypersensitivity which leads to increased degranulation, which further ups PGD2 levels, and so on and so forth
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