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The proteomic results suggested that the immunoproteasome subunit β5i was decreased in livers from ibuprofen treated male mice and Western blotting and proteasome assays suggest gender-specific differences with respect to proteasome and immunoproteasome activities

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As shown in Figure 4C, IL-10 levels in the APP/PS1 group were significantly decreased compared with those in the WT group, and Dihexa-treated APP/PS1 mice had significantly increased levels of IL-10 (Figure 4C)