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Although both cross-sectional and longitudinal studies confirm that mean GFR declines with age, there is significant individual variation - not everyone has a precipitous decline in kidney function with age ( 4.3 Diabetic nephropathy Around 1/3 of people diagnosed with type 1 diabetes and nearly 1/2 those with type 2 diabetes will develop diabetic nephropathy (DN) at some stage in their lives

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